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目的探讨胰岛细胞肿瘤的诊断和治疗,对胰岛细胞肿瘤发病情况进行分析。方法回顾性分析1953～2003年浙江大学医学院附属第二医院收治的胰岛细胞肿瘤35例,并结合国内有关文献报道进行诊治分析。结果35例胰岛细胞肿瘤经手术切除病理证实33例,其中胰岛素瘤24例(72.7%,24/33),无功能胰岛细胞瘤7例(21.2%,7/33),胰高糖素瘤、胃泌素瘤各1例。国内同期文献报道胰岛细胞肿瘤2785例。结论胰岛细胞瘤主要是胰岛素瘤和无功能胰岛细胞瘤,其他肿瘤少见。对良性者宜行单纯肿瘤切除或胰腺部分切除,对恶性肿瘤应采用扩大范围的根治性肿瘤切除术为主的综合治疗,预后好于其他腹腔内脏器肿瘤。
Objective To investigate the diagnosis and treatment of islet cell tumors and to analyze the incidence of islet cell tumors. Methods A retrospective analysis of 35 cases of islet cell tumors admitted to the Second Affiliated Hospital of Zhejiang University from 1953 to 2003, combined with the domestic literature reports for diagnosis and treatment. Results Thirty-three cases of pancreatic islet cell tumors were confirmed by surgical resection. There were 24 cases of insulinoma (72.7%, 24/33), 7 cases of non-functioning islet cell tumor (21.2%, 7/33), glucagonoma, Gastrinoma in 1 case. In the same period, 2785 cases of islet cell tumors were reported in the country. Conclusion The islet cell tumor is mainly insulinoma and non-functional islet cell tumor, other tumors are rare. For benign patients should be simple tumor resection or partial resection of the pancreas, malignant tumors should be used to expand the scope of radical resection of the main treatment, the prognosis is better than other abdominal visceral tumors.