尼扎替丁(nizatidine)为N-[2-[[[2-[(二甲氨基)甲基]-4-噻唑]中基]硫代]乙基]-N’-甲基-2-硝基-1,1-次乙基二胺,是新的组胺H_2-受体拮抗剂,表现为抑制胃酸分泌和抗溃疡活性。它对离体大鼠子宫的拮抗活性比西咪替丁强10倍,其pA_2值分别为7.06和6.06。当临床应用时,组胺拮抗剂如西咪替丁和雷尼替丁增加血浆促胃液素水平。有报道停止应用尼扎替丁后增加夜间酸分泌,因此提出停用这些药物后溃疡复发的可能性。 Nizatidine is a thio] ethyl] -N’-methyl-2- (2-dimethylaminomethyl) -4-thiazolyl] Nitro-1,1-ethanediamine, a new histamine H 2 -receptor antagonist, appears to inhibit gastric acid secretion and anti-ulcer activity. Its isolated rat uterus antagonistic activity than cimetidine 10 times stronger, pA_2 values ​​were 7.06 and 6.06. Histamine antagonists such as cimetidine and ranitidine increase plasma gastrin levels when clinically used. There have been reports of nocturnal use of nocturnal supplementation to increase nocturnal acid secretion, thereby proposing the possibility of ulcer recurrence after discontinuation of these drugs.