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观察了10例肝硬化基础上发生的慢性重症肝炎。肝穿刺标本(除2例经治疗好转第二次穿刺者外)均有大块和亚大块肝细胞坏死。早期表现为:大片肝细胞细胞变小,互相离解;或胞质肿胀,嗜酸性增强;或着色清淡,质膜破裂;核浓缩、变形或溶解消失。再进一步发展则是大片肝细胞坏死,假小叶结构开始
Chronic severe hepatitis occurred on the basis of 10 cases of cirrhosis. Liver puncture specimens (except for 2 cases that were cured by the second puncture after treatment) had massive and sub-massive hepatocyte necrosis. Early manifestations are: large areas of hepatocytes become smaller and dissociate from each other; or cytoplasm swells, eosinophilic increases; or lightly colored, the plasma membrane ruptures; nuclear condensation, deformation, or dissolution disappears. Further development is large necrosis of hepatocytes, and the formation of pseudolobules begins.