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目的:探讨右美托咪定预处理对肝脏手术后患者肺损伤的影响。方法选择2009年8月到2014年2月在我院择期行肝脏手术患者60例,根据随机抽签原则分为治疗组与对照组各30例,2组均给予单肺通气麻醉,与对照组不同的是治疗组麻醉诱导后选择持续静脉泵注右美托咪定;所有患者于麻醉诱导前(T0)、关胸(T1)、术后即刻(T2)进行血气分析、炎症因子表达检测与肺部功能分析。结果2组舒张压和心率在3个时间点(T0、T1、T2)组内和组间比较差异均无统计学意义(P>0.05)。2组T1与T2时间点的TNF-α和SP-D表达量明显高于T0时间点(P<0.05),同时T1与T2时间点治疗组的TNF-α和SP-D表达量明显低于对照组(P<0.05)。治疗组T2、T3时间点的气道平台压和气道阻力明显低于T1时间点(P<0.05),与对照组对比差异也有统计学意义(P 0. 05). And the expression of TNF-αand SP-D at time points of T1 and T2 in the two groups were significantly higher than those at T0 (P<0. 05);while the expression of TNF-αand SP-D in the treatment group were significantly lower than those in the control group at time points of T1 and T2 (P<0. 05). The plateau air-way pressure and airway resistance in the treatment group at T2 and T3 were significantly lower than that at T1 (P<0. 05), and there were statistically significant differences compared with the control group (P<0. 05). Conclusion The dexmedetomidine pretreatment for the liver surgery patients can inhibit the inflammatory response, while improve lung airway plateau pressure and airway resistance. It has no significant effect for blood, so it can play a protective role for lung function.