目的了解石狮市肾综合征出血热(HFRS)发病及鼠间感染情况。方法开展流行病学调查和宿主监测,调查鼠密度和鼠类带毒率,分析疫情。结果 2007—2015年石狮市HFRS报告病例117例,年发病率2.23/10万,呈逐年增加趋势。全年均有病例发生,呈春、秋双峰型分布;全市9个镇/街道均有病例报告,有67.5%的病例集中在市周边的4个镇/街道;病例性别比2.51,以青壮年为主(72.6%),职业以民工较多(19.7%)。2014、2015年平均鼠密度分别为5.4%、6.9%,鼠带毒率20.0%。结论石狮市肾综合征出血热发病率及鼠间带毒率较高,应加强综合治理措施控制疫情。 Objective To understand the incidence of hemorrhagic fever with renal syndrome (HFRS) and the infection among mice in Shishi City. Methods To carry out epidemiological investigation and host monitoring, investigation of rat density and rodent rate, analysis of epidemic. Results A total of 117 HFRS cases were reported in Shishi City from 2007 to 2015, with an annual incidence rate of 2.23 / 100 000, showing an increasing trend year by year. In the whole year, 9 cases were reported in the towns and townships, 67.5% of cases were concentrated in 4 towns / streets around the city; the sex ratio of cases was 2.51, Mainly young and middle-aged (72.6%), employment more migrant workers (19.7%). The average rat densities in 2014 and 2015 were 5.4% and 6.9%, respectively, and the rate of rat poisoning was 20.0%. Conclusion The incidence of hemorrhagic fever with renal syndrome in Shishi City is higher than that in other cities. The integrated control measures should be strengthened to control the epidemic.