Acute myocardial infarction (AMI) is a clinical syndrome of myocardial ischemia and necrosis caused by acute blocking of the coronary artery. When complicated by cardiogenic shock (CS), it has an extremely high mortality.(1,2) Early reperfusion therapy combined with left ventricular assist device (LVAD) can raise the survival rate to 58.8%–60.9%.(3) We report a case of successful treatment with integrated Chinese and Western medicine on acute extensive anterior myocardial infarction complicated by refractory CS.rnCase PresentationrnThe First StagernA 46 years old male patient received an emergency treatment due to “chest pain lasts for 1 h” on January 10th, 2014. The ST segments of ECG Ⅰ, aVL and V1-V6 elevated by 0.1–1.0 mV, blood pressure (BP): 80/42 mm Hg, heart rate (HR): 100 beat/min, SO2: 95%. He was diagnosed as extensive anterior myocardial infarction associated with hypotension. After first medical contact, doctors suggested the patient should be given percutaneous coronary intervention (PCI) immediately, which was rejected by the patient and his family. After 2 h delay, the patient eventually received a thrombolytic therapy by giving 100 mg intravenous thrombolysis of alteplase.