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目的 :比较研究心痛灵滴丸预适应与缺血预适应对兔缺血再灌注损伤心肌的保护作用。方法 :4 0只冠状动脉粥样硬化 (AS)家兔随机分为假手术对照 (SOC)组、缺血再灌注 (I R)组、心痛灵滴丸预适应 (XTL)组和缺血预适应 (IPC)组 ,观察心痛灵滴丸预适应和缺血预适应对心肌缺血再灌注时左室收缩压峰值 (LVSP)、左室舒张末期压 (LVEDP)、等容收缩期左室内压最大上升速率 (+dp dtmax)、等容舒张期左室内压最大下降速率 (-dp dtmax)、乳酸脱氢酶 (LDH)、肌酸磷酸激酶同工酶(CK MB)、三磷酸腺苷 (ATP)、血清超氧化物歧化酶 (SOD)、丙二醛 (MDA)的影响。结果 :心痛灵滴丸预适应与缺血预适应均能改善缺血再灌注时左心室功能 ,减少心肌LDH、CK MB的漏出 ,提高心肌ATP含量和血清SOD活性 ,降低MDA含量。结论 :心痛灵滴丸预适应能诱导心肌缺血预适应样保护作用。
Objective : To compare the protective effect of Xintongling Pills preconditioning and ischemic preconditioning on myocardial ischemia and reperfusion injury in rabbits. METHODS: Forty rabbits with coronary atherosclerosis (AS) were randomly divided into sham control group (SOC) group, ischemia reperfusion (IR) group, Xintongling Pill Preconditioning (XTL) group and ischemic preconditioning. In the IPC group, the observation of Xintongling Pills Preconditioning and Ischemic Preconditioning on Left Ventricular Systolic Blood Pressure (LVSP), Left Ventricular Diastolic End Pressure (LVEDP), and Left Ventricular Hypertension during Isovolumic Systolic Myocardial Ischemia/Reperfusion Ascending rate (+dp dtmax), maximum rate of left ventricular pressure during isovolumic relaxation (-dp dtmax), lactate dehydrogenase (LDH), creatine phosphokinase isoenzyme (CK MB), adenosine triphosphate (ATP), serum The effect of superoxide dismutase (SOD) and malondialdehyde (MDA). RESULTS: Pretreatment of Xintongling Pills and ischemic preconditioning both improved left ventricular function during ischemia-reperfusion, reduced leakage of myocardial LDH and CK MB, increased myocardial ATP content and serum SOD activity, and decreased MDA content. Conclusion : Pretreatment of Xintongling Pills can induce myocardial ischemic preconditioning.