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目的:研究山蛩提取物在小鼠体内对肝癌H_(22)移植瘤生长的影响。方法:肝癌H_(22)荷瘤小鼠随机分为5组:模型组、山蛩提取物低、中、高(0.40、0.80、1.60g·kg~(-1))3个剂量组和阳性药五氟尿嘧啶(5-FU,5mg·kg~(-1))对照组。连续给药13天,于第14天检测抑瘤率、脾指数、胸腺指数、血清中AST和ALT的活性。结果:与模型组比较,山蛩提取物低、中、高剂量组的抑瘤率分别为27.14%(P<0.05)、35.31%(P<0.01)和40.25%(P<0.01);同阳性组相比,山蛩提取物高、中、低剂量组的荷瘤小鼠脾脏指数及胸腺指数均显著升高(P<0.05)。结论:山蛩提取物对肝癌H_(22)荷瘤小鼠肿瘤的生长具有明显的抑制作用,并能保护荷瘤小鼠的免疫功能,其机制可能与其促进胸腺和脾腺产生抑瘤因子有关。
OBJECTIVE: To study the effect of extract of Rhizoma Pinelliae on the growth of H_ (22) transplanted hepatocarcinoma in mice. Methods: H22 tumor-bearing mice with hepatocellular carcinoma were randomly divided into 5 groups: model group, sham group, low dose group, middle dose group and high dose group (0.40,0.80,1.60g · kg -1) Drug five fluorouracil (5-FU, 5mg · kg -1) control group. Administration was continued for 13 days. On the 14th day, the tumor inhibition rate, spleen index, thymus index, serum AST and ALT activity were detected. Results: Compared with the model group, the tumor inhibition rates of shark extract in low, medium and high dose groups were 27.14% (P <0.05), 35.31% (P <0.01) and 40.25% (P <0.01) Compared with the sham group, the spleen index and thymus index of tumor-bearing mice in sham group, high dose group, medium dose group and low dose group were significantly increased (P <0.05). CONCLUSION: The extract from Shanyang can significantly inhibit the growth of H22 tumor-bearing mice and protect the immune function of tumor-bearing mice. The mechanism may be related to the promotion of anti-tumor growth factors in thymus and spleen gland .