论文部分内容阅读
目的探讨皮质脊髓束磁共振弥散张量成像(DTI)对帕金森病(PD)和帕金森叠加综合征(PPS)的鉴别诊断价值。方法对34例PD、10例多系统萎缩-帕金森型(MSA-P)、10例进行性核上性麻痹(PSP)患者进行DTI扫描,采用手绘兴趣区的方法,在各向异性分数(FA)图上测量皮质束各层面(内囊、中脑、脑桥、延髓)的FA值,结果采用单因素方差分析进行统计。结果与PD患者比较,MSA-P患者内囊、中脑、脑桥等层面的FA值明显下降(P<0.05)。PSP患者仅在中脑和右侧内囊层面FA值明显降低(P<0.05)。PSP患者左侧中脑FA值低于MSA-P患者,差异有统计学意义(P<0.05)。在延髓水平,各组患者间的FA值差异无统计学意义(P>0.05)。结论利用皮质脊髓束DTI可以鉴别PD与PPS。
Objective To investigate the differential diagnosis of Parkinson’s disease (PD) and Parkinson’s syndrome (PPS) with corticospinal tract magnetic resonance diffusion tensor imaging (DTI). Methods DTI scanning was performed on 34 patients with PD, 10 patients with multiple system atrophy - Parkinsonism (MSA-P) and 10 patients with progressive supranuclear palsy (PSP). The hand-drawn region of interest FA) FA values measured at various levels of the cortical bundles (internal capsule, midbrain, pons, medulla oblongata) were calculated. The results were statistically analyzed by one-way ANOVA. Results Compared with PD patients, the FA values of MSA-P in the inner capsule, midbrain and pons were significantly decreased (P <0.05). In patients with PSP, the FA value was significantly decreased only in the midbrain and the right internal capsule (P <0.05). The left midbrain FA in PSP patients was lower than that in MSA-P patients (P <0.05). At the medullary level, there was no significant difference in FA between the groups (P> 0.05). Conclusion The use of corticospinal tract DTI can distinguish PD and PPS.