论文部分内容阅读
作者研究了一个简单而有普遍意义的予测个体剂量的方法——一点法。即只需根据病人首次用药后某个时间测得的一次血药浓度来予测剂量的方法。 1.予测药物稳定态的研究简单而有普遍性的确定剂量的方法应立足于从病人首次用药之后取得的极少量数据中,提取出最大限度的药物动力学信息。研究结果表明,稳定态水平与首次用药后一次血药浓度之间有密切的相关关系。因此可以从病人首次用药后某个时间测得的一次血药
The authors studied a simple but universal way of predicting individual dosages - the one-point method. That is, only the dose is measured according to a blood concentration measured at a certain time after the first administration of the drug. 1. Predicted drug stability studies A simple and universal method of determining doses should be based on the maximum amount of pharmacokinetic information extracted from the very small amount of data obtained after the patient has been given the drug for the first time. The results show that there is a close correlation between the steady-state level and the first plasma concentration after the first administration. Therefore, the patient can be measured once at a time after the first administration of blood drug