碳青霉烯类抗菌药物具有广泛的抗菌活性,是治疗革兰阴性杆菌感染的一线药物。随着应用的增加,耐药性的问题日益严重。碳青霉烯酶是目前发现肠杆菌科细菌对碳青霉烯类抗菌药物耐药的主要机制。准确快速检测这些耐药基因是控制其传播的关键。本研究对碳青霉烯酶基因型的研究进展进行综述。 Carbapenems antibacterial drugs have a wide range of antibacterial activity, is the first-line drug for the treatment of Gram-negative bacilli. With the increase of applications, the problem of drug resistance is becoming more and more serious. Carbapenemase is the main mechanism of Enterobacteriaceae resistance to carbapenem antibiotics. Accurate and rapid detection of these resistance genes is the key to control their spread. In this study, the research progress of carbapenemase genotypes were reviewed.