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目的了解《中国儿童和妇女发展纲要(2011-2020年)》(以下简称《新两纲》)中期中国内地各区县婚检人群梅毒感染率状况,揭示婚检人群梅毒感染率变化趋势,促进中国婚检工作发展,提升婚检机构的性病防治水平。方法检索中文数据库,收集整理2011年1月1日-2016年6月30日公开发表的针对中国内地婚检人群的文献进行回顾性分析,使用SPSS17.0软件进行统计学分析,用卡方检验对梅毒感染率进行分析。结果中国内地各区县婚检人群梅毒总感染率加权平均为0.325%,其中广西壮族自治区防城港婚检人群的感染率为1.03%,明显高于全国其他各区县(0.11%~1.03%)。通过统计分析,中国内地各区县婚检人群梅毒感染率差异有统计学意义(χ~2=637.322,P<0.001),华南、华东和西南三个大区之间婚检人群梅毒感染率差异有统计学意义(χ~2=31.702,P<0.001),但男性与女性梅毒感染率差异无统计学意义(χ~2=0.478,P=0.489)。对三个大区梅毒感染率进行Pearson卡方与两两比较,华南与华东地区梅毒感染率差异有统计学意义(χ~2=20.684,P<0.001),华南与西南地区梅毒感染率差异有统计学意义(χ~2=19.173,P<0.001)。华东与西南地区梅毒感染率差异无统计学意义(χ~2=2.908,P=0.088)。华南和华东地区、长江和珠江三角洲地区婚检人群梅毒感染率处于较高水平,可能与当地经济状况、文化教育程度、地方性风俗习惯、人口流动性、婚检意识、医疗水平和预防干预措施的差异有关。结论中国内地各区县婚检人群梅毒感染率近几年有增高趋势,地区差异大,中国各级政府、婚检和疾控机构应加强合作和监管,只有形成合力才能阻断传染病传播,避免胎传性梅毒的发生,减少出生缺陷发生率,维护家庭与社会的稳定与和谐。
Objectives To understand the prevalence of syphilis among premarital people in all districts and counties in the mid-term in the “Outline for the Development of Children and Women in China (2011-2020)” (hereinafter referred to as “the new two guidelines”), to reveal the trend of syphilis infection among premarital people and to promote premarital examination in China Development, enhance the level of STD prevention and treatment of premarital institutions. Methods The Chinese database was searched and collected. The literature published on January 1, 2011 - June 30, 2016 on the premarital population in the Mainland of China was collected and analyzed retrospectively. The data were analyzed by SPSS 17.0 software. Syphilis infection rates were analyzed. Results The prevalence of syphilis was 0.325%. The prevalence of the syphilis infection was 1.03% in Fangchenggang, Guangxi Zhuang Autonomous Region, which was significantly higher than that of other districts and counties in the country (0.11% -1.03%). Through statistical analysis, there was significant difference in syphilis infection rates between premarital patients in all districts and counties in mainland China (χ ~ 2 = 637.322, P <0.001). There were statistically significant differences in syphilis infection rates between premarital patients in three regions of South China, East China and Southwest China (Χ ~ 2 = 31.702, P <0.001). However, there was no significant difference in syphilis infection rates between male and female (χ ~ 2 = 0.478, P = 0.489). The syphilis infection rates in three districts were compared by Pearson Chi-square test and pairwise comparison. There was significant difference in syphilis infection rates between South China and East China (χ ~ 2 = 20.684, P <0.001). There was significant difference in syphilis infection rates between South China and Southwest China Statistical significance (χ ~ 2 = 19.173, P <0.001). There was no significant difference in syphilis infection rates between East China and Southwest China (χ ~ 2 = 2.908, P = 0.088). The rates of syphilis infection among premarital people in South China and East China, the Yangtze River and the Pearl River Delta are at a high level, which may be related to the local economic conditions, education levels, local customs, population mobility, premarital conscientiousness, medical standards and preventive interventions related. Conclusions Syphilis infection rate among premarital patients in all districts and counties in Mainland China has been on the rise in recent years with large differences in areas. The Chinese government at all levels, premarital examination and CDC should strengthen cooperation and supervision, and only concerted efforts can stop the spread of infectious diseases and avoid the spread of the fetuses Syphilis occurs, reducing the incidence of birth defects and safeguarding the stability and harmony of family and society.