本文比较了实验性矽肺大鼠和正常大鼠肺中能为胃蛋白酶限制性降解法溶出的不溶性胶原的百分含量,并比较了它们的SDS-巯基乙醇间断凝胶电泳图谱。我们从结果中观察到,矽肺大鼠肺胶原中不能为胃酶限制性降解的成份较多,但在其为胃酶降解溶出的胶原中能被巯基试剂还原的Ⅲ型胶原含量较少。 In this paper, the percentages of insoluble collagen that can be released by pepsin restriction degradation in the lungs of experimental and normal rats were compared, and their SDS-mercaptoethanol gel electrophoresis profiles were compared. We have observed from the results that there are more components that can not be restrictedly degraded by pepsin in the lung collagen of silicotic rats, but the content of type III collagen which can be reduced by thiol reagent in the collagenolytic enzyme is less.