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目的观察氯沙坦联合甲钴铵(弥可保)治疗糖尿病周围神经病变(DNP)的临床价值。方法糖尿病患者124例分为实验组和对照组,每组62例,两组患者均予以弥可保肌内注射治疗,具体剂量为500μg q.d.,治疗疗程均为3个月,实验组在此基础上联合予以口服氯沙坦,具体剂量为50 mg q.d.,治疗疗程为3个月,比较两组患者血糖状况、痛觉过敏及减退等临床症状。结果实验组治疗3个月后痛觉过敏及减退有效率为80.65%、79.03%,显著优于对照组的62.90%和59.68%,差异具有统计学意义(P<0.05),实验组和对照组治疗后空腹血糖均有显著降低,组间差异有统计学意义(P<0.05)。结论氯沙坦联合弥可保应用于DPN能明显改善患者症状,提高临床有效率,具有服用方便、不良反应少,患者依从性好的优点,值得临床借鉴。
Objective To observe the clinical value of losartan combined with mecobalamin in the treatment of diabetic peripheral neuropathy (DNP). Methods One hundred and twenty-four diabetic patients were divided into experimental group and control group, with 62 cases in each group. Both groups were treated with intramuscular injection of Mi Ke Bao Ji, the specific dose was 500 μg qd, and the treatment course was 3 months. On the joint oral losartan, the specific dose of 50 mg qd, the course of treatment for 3 months, comparing the two groups of patients with blood glucose status, hyperalgesia and clinical symptoms such as diminished. Results The effective rate of hyperalgesia and hypoalgesia was 80.65% and 79.03% respectively in experimental group 3 months later, which was significantly better than 62.90% and 59.68% in control group (P <0.05). The experimental group and control group After fasting blood glucose were significantly reduced, the difference between groups was statistically significant (P <0.05). Conclusion The application of losartan combined with miconazole in DPN can significantly improve the symptoms and improve the clinical efficiency. It has the advantages of easy to take, less adverse reactions and good compliance of patients. It deserves clinical reference.