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目的:探讨新疆哈萨克族原发性高血压(EH)人群中血管紧张素原(AGT)基因M235T和T174M多态性的分布及其与EH伴左室肥厚(LVH)的关系。方法:对86例心电图诊断的EH伴LVH患者(LVH组)与95例不伴LVH患者(NLVH组)进行病例-对照研究,即记录标准12导联以传统的电压诊断标准与Romhilt计分系统积分作为诊断LVH的指标。采用聚合酶链式反应(PCR)与限制性片段长度多态性(RFLP)技术检测AGT基因M235T变异及T174M变异。结果:①M235T基因型有2种形式,T174M基因型有3种形式;2组AGT基因型的分布均符合Hardy-Weinberg平衡;②AGT基因M235T和T174M基因型及等位基因在LVH组与NLVH组的分布均差异无统计学意义(均P>0·05);③按性别分层,M235T基因型和等位基因频率在2组男女之间均差异无统计学意义(均P>0·05);T174M基因型和等位基因频率在LVH组男女之间亦均差异无统计学意义(均P>0·05),而在NLVH组男女之间差异有统计学意义(均P<0·05);④AGT基因M235T,T174M位点不同组合基因型在2组人群的构成不存在显著性差异(P>0·05)。结论:AGT基因M235T及T174M多态性与新疆哈萨克族EH伴LVH的发生无相关性。AGT基因M235T及T174M多态性可能不是新疆哈萨克族EH伴LVH的遗传危险因素。
Objective: To investigate the distribution of the M235T and T174M polymorphisms of angiotensinogen (AGT) gene and their association with left ventricular hypertrophy (EH) with left ventricular hypertrophy (LVH) in Kazak people with essential hypertension (EH). Methods: A case-control study was performed in 86 patients with EH with LVH (LVH group) and 95 patients with non-LVH (NLVH group) diagnosed by electrocardiogram. The standard 12-lead recording was performed with the conventional voltage diagnostic criteria and Romhilt scoring system Integral as an indicator of LVH diagnosis. The M235T mutation and T174M mutation of AGT gene were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: ①M235T genotypes had 2 forms and T174M genotypes had 3 forms. The AGT genotype distributions of both groups were in line with Hardy-Weinberg equilibrium; ②AGT gene M235T and T174M genotypes and alleles in LVH group and NLVH group There was no significant difference in the distribution of M235T genotypes and alleles between the two groups (all P> 0.05) ; There was no significant difference in genotype and allele frequencies of T174M between men and women in LVH group (all P> 0.05), but there was significant difference between men and women in NLVH group (P <0.05) ); ④The genotypes of AGT gene M235T and T174M did not show any significant difference in the two groups (P> 0.05). CONCLUSION: There is no correlation between AGT gene M235T and T174M polymorphism and the occurrence of EH with LVH in Kazak of Xinjiang. The AGT gene M235T and T174M polymorphisms may not be the genetic risk factors of EH with LVH in Kazak of Xinjiang.