目的 :了解肾移植术后患者应用地尔硫对环孢素A (CsA)血药浓度的影响及肾保护作用。方法 :选用25例肾移植患者分为两组 ,治疗组加用地尔硫 ,采用荧光偏振免疫分析法测定CsA的全血谷浓度。结果 :治疗组CsA的用量明显低于对照组 ,地尔硫能降低尿酸、血清肌酐、尿素氮水平。结论 :地尔硫能减少CsA用量 ,防护CsA肾毒性 ,还可减少患者费用 Objective: To investigate the effect of diltiazem on plasma concentration of CsA and renal protection in renal transplant recipients. Methods: Twenty-five renal transplant recipients were divided into two groups. Diltiazem was added to the treatment group, and the whole blood concentration of CsA was measured by fluorescence polarization immunoassay. Results: The dosage of CsA in the treatment group was significantly lower than that in the control group. Diltiazem could reduce uric acid, serum creatinine and urea nitrogen. Conclusion: Diltiazem can reduce CsA dosage and protect CsA nephrotoxicity, and can also reduce the cost of patients