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目的探讨美沙酮门诊患者抗病毒治疗服药依从性对CD4~+ T淋巴细胞计数的影响。方法对2006年9月-2015年12月乌鲁木齐市水磨沟区美沙酮门诊接受抗病毒治疗的216例AIDS吸毒患者作为研究对象,对患者的抗病毒治疗服药情况进行问卷调查,分析抗病毒治疗依从性对CD4~+ T淋巴细胞计数的影响。结果依从性好的患者占56.94%,依从性差的占43.06%。治疗1年后依从性好的CD4~+ T淋巴细胞计数由治疗前的(294.91±183.56)cells/mm3上升到治疗后的(466.28±215.80)cells/mm~3,差异有统计学意义(P<0.05);依从性不好的CD4~+ T淋巴细胞计数治疗前后差异无统计学意义[306.91±185.481 vs.(293.97±192.83)]cells/mm3,P>0.05);依从性好的组患者在多因素Logistic回归模型分析中,性别、年龄、感染途径与抗病毒治疗CD4~+ T淋巴细胞计数的关系差异无统计学意义(P>0.05)。在多因素Logistic回归模型分析中,抗病毒治疗相关知识(OR=2.369,95%CI:3.624~7.987)、按照要求的次数服药(OR=2.342,95%CI:3.259~6.421)、按照要求的量服药(OR=2.688,95%CI:5.632~8.145)、按要求的时间定时服药(OR=3.256,95%CI:6.014~9.875)、按照要求长期坚持从不间断(OR=4.123,95%CI:6.984~11.251)、家人提醒按时服药(OR=1.987,95%CI:4.709~8.209)是CD4~+ T淋巴细胞计数高低的重要影响因素,差异有统计学意义(P<0.05)。结论 CD4~+ T淋巴细胞计数是反映艾滋病患者依从性高低的较好指标,抗病毒治疗相关知识、按照要求的次数服药、按照要求的量服药、按要求的时间定时服药、按照要求长期坚持从不间断、家人提醒按时服药是影响CD4~+ T淋巴细胞计数的重要影响因素,提高艾滋病患者抗病毒治疗服药依从性,对临床治疗效果具有积极地促进作用。
Objective To investigate the effect of medication compliance of CD4 + T lymphocytes in patients with methadone outpatient antiviral therapy. Methods A total of 216 AIDS drug-resistant patients who received antiviral therapy at the methamphetamine clinic in Shuimogou District, Urumqi from September 2006 to December 2015 were selected as research subjects. Questionnaire investigation was conducted on patients taking antiretroviral therapy, and the compliance of antiretroviral therapy On CD4 ~ + T lymphocyte count. Results Good compliance patients accounted for 56.94%, poor compliance accounted for 43.06%. The compliance of CD4 ~ + T lymphocytes in one year after treatment rose from (294.91 ± 183.56) cells / mm3 to (466.28 ± 215.80) cells / mm ~ 3 after treatment, the difference was statistically significant (P <0.05). There was no significant difference in CD4 ~ + T lymphocyte count with poor compliance between before and after treatment [306.91 ± 185.481 vs. (293.97 ± 192.83)] cells / mm3, P> 0.05) In the multivariate Logistic regression model analysis, there was no significant difference in the relationship between gender, age, infection and CD4 ~ + T lymphocyte count of antiviral therapy (P> 0.05). In the multivariate Logistic regression model analysis, the knowledge of antiviral therapy (OR = 2.369, 95% CI: 3.624-7.987) was administered according to the required number of times (OR = 2.342,95% CI: 3.259 ~ 6.421) (OR = 3.256, 95% CI: 6.014 ~ 9.875), according to the requirements of long-term adherence without interruption (OR = 4.123, 95% CI: CI: 6.984-11.251). The family members reminded that taking medicine on time (OR = 1.987, 95% CI: 4.709-8.209) was an important factor influencing the level of CD4 ~ + T lymphocyte count (P <0.05). Conclusions CD4 ~ + T lymphocyte count is a good indicator to reflect the level of compliance of patients with AIDS. Knowledge of antiviral therapy should be taken according to the required number of times, taken according to the required amount, timed according to the required time, and insisted upon from long-term Non-stop, family reminded that taking medication on time is an important factor affecting the CD4 ~ + T lymphocyte count, and improving the adherence of anti-viral treatment to AIDS patients, which has a positive effect on clinical treatment.