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目的分析目前治疗急性百草枯中毒方法。方法 74例急性百草枯中毒患者,根据治疗方法不同分为内科治疗组(34例)、血液灌流治疗组(20例)和血液灌流+血液透析治疗组(20例)。内科治疗组给予洗胃、维持水电解质平衡、保护内脏功能等对症支持治疗,血液灌流治疗组在内科治疗的基础上加用血液灌流治疗,血液灌流+血液透析治疗组在内科治疗的基础上加用血液灌流及血液透析联合治疗。比较三组患者治疗效果。结果血液灌流+血液透析治疗组死亡率为20.00%,低于血液灌流治疗组的50.00%(P<0.05),血液灌流+血液透析治疗组及血液灌流治疗组死亡率低于常规内科治疗组的76.47%,差异有统计学意义(P<0.05)。三组患者12 h内开始治疗的患者其预后均明显优于12 h后接受治疗的患者,差异有统计学意义(P<0.05)。结论对于急性百草枯中毒患者血液灌流联合血液透析治疗能够提高治疗效果,改善预后,提升患者存活率。
Objective To analyze the current treatment of acute paraquat poisoning methods. Methods A total of 74 patients with acute paraquat poisoning were divided into two groups: the medical treatment group (34 cases), the hemoperfusion group (20 cases) and the hemoperfusion + hemodialysis group (20 cases). The patients in the medical treatment group were given gastric lavage, maintain the balance of water and electrolyte, protect the symptomatic supportive treatment such as visceral function. The hemoperfusion group was treated with hemoperfusion on the basis of medical treatment. The hemoperfusion + hemodialysis group was based on the medical treatment Hemoperfusion and hemodialysis combined treatment. Compare the treatment effect of three groups of patients. Results The mortality rate in hemoperfusion + hemodialysis group was 20.00%, which was lower than that in hemoperfusion group (50.00%, P <0.05). The mortality in hemoperfusion + hemodialysis group and hemoperfusion group was lower than that in conventional medicine group 76.47%, the difference was statistically significant (P <0.05). The prognosis of patients in three groups who started treatment within 12 hours was significantly better than that of patients who were treated after 12 hours (P <0.05). Conclusion Hemoperfusion combined with hemodialysis in patients with acute paraquat poisoning can improve the therapeutic effect, improve the prognosis and improve the survival rate of patients.