奎尼丁是最古老而又常用的抗心律失常药物,它代谢迅速,半寿期短。研制该药的长效制剂或缓慢释放型制剂,可使给药方案更易为病员接受,并能使其有更恒定的血药浓度。本文比较不同剂型的奎尼丁,在治疗室性心律失常中的疗效和安全性。方法:90名患者于服安慰剂一周后连续作2次 Quinidine is the oldest and most commonly used antiarrhythmic drug, which metabolizes quickly and has a short half-life. The development of the drug’s long-acting formulations or slow-release formulations, the dosing program can be more acceptable to the patient, and can make it a more constant plasma concentration. This article compares the different formulations of quinidine, in the treatment of ventricular arrhythmias efficacy and safety. Methods: Ninety patients were treated twice a week for placebo