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本文介绍了樟柳碱对大鼠脑组织单胺类神经介质含量的影响。用荧光分光光度法测定了药物组和生理盐水组大鼠尾核、海马、间脑、脑干和大脑皮层的去甲基肾上腺素,多巴胺、5-羟色胺和5-羟吲哚乙酸的含量。结果发现,注射樟柳碱后48小时,脑干的去甲基肾上腺素含量显著增高,多巴胺的含量未见明显变化,而各脑区5-羟色胺和5-羟吲噪乙酸的含量在注射樟柳碱后1小时或48小时均显著增高。讨论了脑组织单胺类神经介质与学习和记忆的关系,推测,樟柳碱引起的脑组织5-羟色胺和5-羟吲哚乙酸含量的增高可能与记忆障碍有关。
This article describes the anisodine on rat brain tissue monoamine neurotransmitters. The contents of norepinephrine, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the caudate nucleus, hippocampus, diencephalon, brainstem and cortex of the rats in the drug group and the saline group were determined by fluorescence spectrophotometry. The results showed that, 48 hours after injection of anisodine, the content of norepinephrine in brain stem increased significantly, while the content of dopamine did not change significantly. However, the content of 5-hydroxytryptamine and 5- An hour or 48 hours after the alkali were significantly increased. The relationship between learning and memory of monoamine neurotransmitters in brain tissue was discussed. It is speculated that the increase of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid content induced by anisodine may be related to memory impairment.