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据医学论坛网报道,帕金森病中的步态不稳在某种程度上是由胆碱能缺陷所致,并会造成患者跌倒。《柳叶刀·神经病学》(The Lancet Neurology)近日在线发表的一项研究发现,乙酰胆碱酯酶抑制剂可以改善这一风险。在这项双盲的二期随机试验中,研究者们对130例病情稳定的帕金森病患者进行了研究,这些患者在过去一年中都曾至少跌倒过一次,被给予口服卡巴拉汀(乙酰胆碱酯酶抑制剂通常被用来治疗痴呆症)或安慰剂治疗32周,每天一次。主要终
According to the Medical Forum Network, gait instability in Parkinson’s disease is to some extent caused by cholinergic defects that can cause the patient to fall. A recent online study published in The Lancet Neurology found that acetylcholinesterase inhibitors could improve this risk. In this double-blind, phase II randomized study, 130 patients with Parkinson’s disease who were stable were studied and who had had at least one fall over the past year and were given rivastigmine orally Acetylcholinesterase inhibitors are commonly used to treat dementia) or placebo for 32 weeks once daily. The main end