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本文复习了1964年以来有关非肿瘤性疾病使用免疫抑制药(免抑药)的文献,发现在治疗后伴发急性白血病(急白)61例。原先疾病的诊断多为类风湿关节炎、肾病或多发性硬化等。诊断时年龄为6个月至71岁。免抑药中单用烷化剂者30例(17例用苯丁酸氮芥、8例用环磷酰胺、4例用左旋苯丙氨酸氮芥、1例用马利兰)、单用抗代谢剂10例(8例硫唑嘌呤、1例巯基嘌呤、1例氨甲喋呤)、18例用多种药物及/或放疗。几乎全部病例都使用了大量皮质类固醇治疗。免抑药治疗持续时间自4个月至145个月,平均40个月。从使用免抑药到发生急白
This article reviews the literature on the use of immunosuppressive drugs (anti-suppressive drugs) for non-neoplastic diseases since 1964 and found that there were 61 cases of acute leukemia (acute white) after treatment. The original diagnosis of the disease mostly rheumatoid arthritis, kidney disease or multiple sclerosis. The age of diagnosis is 6 months to 71 years. Thirty patients with alkylating agents alone (17 with chlorambucil, 8 with cyclophosphamide, 4 with melphalan, and 1 with Maryland) were treated with antimetabolite alone 10 cases (8 cases of azathioprine, 1 cases of mercaptopurine, 1 case methotrexate), 18 cases with a variety of drugs and / or radiotherapy. Almost all cases use a large amount of corticosteroids. The duration of anti-depressant treatment ranged from 4 months to 145 months with an average of 40 months. From the use of anti-ineffective to emergency white