癌-睾丸抗原是一种重要的肿瘤标记抗原,由于其表达特异性,以及在发挥抗肿瘤免疫作用的同时,不会对正常组织及生殖细胞产生危害,因此具有用于肿瘤免疫治疗的巨大潜力。其中精子相关抗原作为一种新型的癌-睾丸抗原已成为研究热点之一;精子相关抗原是一类主要表达于精子细胞的抗原,近年来研究表明在某些肿瘤组织中也可检测到其不同程度的表达;本文主要概述了几种研究较为深入的精子相关抗原的生物特性,及其在肿瘤组织中的表达情况以及对肿瘤生物学特性如病理分期、增殖、侵袭、转移等的影响;由于精子相关抗原在多种肿瘤组织中表达具有特异性,并且能够引起体液免疫应答,有可能成为肿瘤早期诊断及免疫治疗的理想靶分子。 Cancer - Testis antigen is an important tumor marker antigen, because of its specificity of expression, as well as exert anti-tumor immune function, while not harmful to normal tissues and germ cells, it has great potential for tumor immunotherapy . Sperm-associated antigens have become one of the hot topics as a new type of cancer-testis antigen. Sperm-associated antigens are a class of antigens that are mainly expressed in sperm cells. In recent years, studies have shown that they can also be detected in some tumor tissues The degree of expression; This article mainly summarizes several studies more in-depth biological characteristics of sperm-related antigens, and its expression in tumor tissue and the biological characteristics of the tumor such as pathological staging, proliferation, invasion, metastasis; due to The expression of sperm-associated antigen in many tumor tissues is specific and can induce humoral immune response, which may become an ideal target for early diagnosis and immunotherapy of tumors.