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目的探讨手术、放疗联合治疗对晚期子宫内膜癌患者生存率与复发率的影响。方法收集病历资料完整的Ⅲ期、Ⅳ期子宫内膜癌病例43例,并根据其有无放疗分为单纯手术组18例、放疗组25例。比较两组5年生存率及复发率。结果 43例患者5年生存率30.23%;1年生存率65.11%(28/43);3年生存率率39.53%(17/43)。放疗组1年生存率与单纯手术组比较有统计学差异(χ2=5.82,P<0.05),而3年、5年生存率虽稍高于单纯手术组,但均无统计学差异(P>0.05)。43例患者5年局部复发率、远处复发率分别为32.56%(14/43)、25.58%(11/43);单纯手术组第5年局部复发率显著高于放疗组(χ2=7.46,P<0.01),两组间远处复发率无统计学差异(P>0.05)。结论对子宫内膜癌Ⅲ期、Ⅳ期患者应强调多种方法综合治疗。手术联合放疗可降低晚期子宫内膜癌患者局部复发率并提高1年生存率,效果确切。
Objective To investigate the effect of combined surgery and radiotherapy on the survival rate and recurrence rate in patients with advanced endometrial cancer. Methods A total of 43 cases with stage Ⅲ and Ⅳ endometrial cancer were collected and divided into 18 cases of simple operation group and 25 cases of radiotherapy group according to the presence or absence of radiotherapy. Five-year survival rate and recurrence rate were compared between the two groups. Results The 43 patients had a 5-year survival rate of 30.23% and a one-year survival rate of 65.11% (28/43). The 3-year survival rate was 39.53% (17/43). The 1-year survival rate of the radiotherapy group was significantly different from that of the simple operation group (χ2 = 5.82, P <0.05), but the 3-year and 5-year survival rates were slightly higher than those of the simple operation group (P> 0.05). The 5-year local recurrence rate and recurrence rate were 32.56% (14/43) and 25.58% (11/43) respectively in 43 patients. The local recurrence rate in the 5-year surgery group was significantly higher than that in radiotherapy group (χ2 = 7.46, P <0.01). There was no significant difference in distant recurrence between the two groups (P> 0.05). Conclusion Endometrial cancer stage Ⅲ, Ⅳ patients should emphasize the comprehensive treatment of multiple methods. Surgery combined with radiotherapy can reduce the local recurrence rate of advanced endometrial cancer patients and improve 1-year survival rate, the exact effect.