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目的:观察转化生长因子β(transforming growth factor-beta,TGFβ)在特纳综合征(Turner syndrome,TS)患者血清中的变化及其与内分泌和心血管参数的关系。方法:选择TS患者和健康志愿者妇女(对照组)各40例,采用酶联免疫方法测定血清中的TGFβ1、TGFβ2及转化生长因子受体(endoglin)。所有TS患者均行心血管系统磁共振和超声检查。结果:TS患者血清中TGFβ1和endoglin水平均高于对照组(P<0.000 1),而TGFβ2的水平则低于对照组(P<0.000 1)。TGFβ的改变与年龄、血压、血小板、甲状腺功能、体重指数或心血管疾病的分型无关。结论:TS患者血清中TGFβ显著性改变对疾病的研究具有重要意义。
Objective: To investigate the changes of serum TGFβ in serum of patients with Turner syndrome (TS) and its relationship with endocrine and cardiovascular parameters. Methods: Forty female patients (control group) with TS and healthy volunteers were enrolled. Serum TGFβ1, TGFβ2 and transforming growth factor receptor (endoglin) were detected by ELISA. All TS patients underwent cardiovascular system magnetic resonance and ultrasonography. Results: The levels of TGFβ1 and endoglin in serum of TS patients were significantly higher than those of the control group (P <0.000 1), while the levels of TGFβ2 were lower than those of the control group (P <0.000 1). Changes in TGFβ are not associated with age, blood pressure, platelets, thyroid function, body mass index or type of cardiovascular disease. Conclusion: The significant change of TGFβ in the serum of patients with TS is of great significance for the study of the disease.