Background:Whether Helicobacter pylori infection is associated with diabetic gastroparesis (DGP) is unclear.This study aimed to investigate the potential correlation between H.pylori infection and DGP.Methods:In this study,163 patients with type 2 diabetes mellitus and 175 nondiabetic patients who were treated in our department were divided into DGP,simple diabetes,non-DGP (NDG),and normal groups based on their conditions.The H.pylori infection rate in each group was calculated.H.pylori eradication therapy was performed for patients with H.pylori infection in each group.The eradication rates were compared between the groups,and the improvements in gastroparesis-associated symptoms were compared before and after treatment in patients with DGP.Results:The H.pylori infection rate was 74.6％ in the DGP group,which was significantly higher than that in the simple diabetes (51.1％,P ＜ 0.01),NDG (57.7％,P ＜ 0.05),and normal groups (48.0％,P ＜ 0.01).With increased disease course,the incidence of DGP and the H.pylori infection rate gradually increased (P ＜ 0.05).In the DGP group,the incidences of upper abdominal pain and distention,early satiety,and anorexia were 75.5％,66.0％,and 67.9％,respectively,before eradication treatment;and 43.4％,35.8％,and 39.6％,respectively,after eradication treatment,and the difference was statistically significant (P ＜ 0.01).In patients with DGP with successful H.pylori eradication,the number of barium strips discharged after eradication was 5.9 + 1.0,which was significantly larger than that before treatment (4.1 ± 0.7,P ＜ 0.01).In addition,the number of barium strips discharged was significantly larger in patients with DGP with successful H.pylori eradication than those with failed H.pylori eradication (P ＜ 0.01).Conclusions:DGP development might be associated with H.pylori infection.H.pylori eradication can effectively improve dyspepsia-associated symptoms and delayed gastric emptying in patients with DGP.