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乳腺癌是一类与多基因相关的恶性肿瘤,有些痛基因如HER-2(c-erbB-2,Neu),bcl-2/6cl-xL,蛋白激酶A(PKA),运铁蛋白受体基因(TfR gene)等的过度表达对乳腺癌的预后有明显影响,有证据表明抑制上述过度表达基因能明显改善乳腺痛的治疗效果。近年,反义治疗这种能抑制特定癌基因过度表达的有效手段被应用于乳腺癌的治疗。研究表明,在多数情况下,反义寡核苷酸(ON)能在mRNA或蛋白水平抑制目的基因的表达,有些反义ON在体和离体对乳腺癌细胞系或动物乳腺癌异植肿瘤均显示出令人鼓舞的治疗效果。此外,反义ON与常规化疗药物合用也能产生协同的抗肿瘤作用。反义ON与化疗药物合用可能在不远的将来是治疗乳腺癌的最佳方法之一。
Breast cancer is a type of multi-gene related malignancy. Some pain genes such as HER-2 (c-erbB-2, Neu), bcl-2 / 6cl-xL, protein kinase A (PKA), transferrin receptor The overexpression of gene (TfR gene) has a significant impact on the prognosis of breast cancer. There is evidence that inhibiting the above overexpression genes can significantly improve the therapeutic effect of breast pain. In recent years, antisense therapy, an effective means of inhibiting the overexpression of a specific oncogene, has been applied to the treatment of breast cancer. In most cases, it has been shown that antisense oligonucleotides (ON) inhibit the expression of genes of interest at the mRNA or protein level. Some antisense ON in vitro and in vivo have been shown to inhibit the proliferation of breast cancer cell lines or animal breast cancer xenografts All show encouraging therapeutic effects. In addition, antisense ON and conventional chemotherapy drugs can also produce a synergistic anti-tumor effect. Antisense ON and chemotherapy drugs may be one of the best ways to treat breast cancer in the near future.