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目的:探讨激素替代疗法治疗围绝经期综合征患者效果及对血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)的影响。方法:选择该院收治的围绝经期综合征患者266例,按照随机数字表法将患者分为观察组和对照组各133例。对照组给予谷维素联合维生素B6治疗;观察组给予激素替代疗法治疗。两组患者疗程均为3周。对比分析两组患者疗程结束后疗效,治疗前后E2、FSH、LH水平变化及子宫内膜厚度和Kupperman症状评分,不良反应发生情况。结果:观察组治疗后总有效率(92.48%)显著高于对照组(70.68%),且差异具有统计学意义(P<0.05);观察组治疗后E2水平显著高于对照组,FSH、LH水平显著低于对照组,且差异均具有统计学意义(P<0.05);观察组治疗后子宫内膜厚度明显厚于对照组,且差异具有统计学意义(P<0.05);观察组治疗后Kupperman症状评分明显低于对照组,且差异具有统计学意义(P<0.05);两组患者治疗过程中均未发生明显不良反应。结论:激素替代疗法治疗围绝经期综合征患者效果明显,有效地改善患者症状和激素水平,保护子宫内膜,且不良反应少,值得临床推广应用。
Objective: To investigate the effect of hormone replacement therapy on patients with perimenopausal syndrome and its effect on serum estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Methods: A total of 266 patients with perimenopausal syndrome admitted to our hospital were selected and divided into observation group (133 cases) and control group (133 cases) according to random number table. The control group was given oryzanol combined with vitamin B6 treatment; the observation group was given hormone replacement therapy. Two groups of patients were treated for 3 weeks. The curative effect of the two groups after the end of treatment was compared and analyzed. The changes of E2, FSH and LH levels, the endometrial thickness and Kupperman symptom scores and the adverse reactions were observed before and after treatment. Results: The total effective rate (92.48%) in the observation group was significantly higher than that in the control group (70.68%), and the difference was statistically significant (P <0.05). The E2 level in the observation group was significantly higher than that in the control group (P <0.05). The thickness of endometrium in the observation group was significantly thicker than that in the control group (P <0.05), and the difference was statistically significant (P <0.05) Kupperman symptom score was significantly lower than the control group, and the difference was statistically significant (P <0.05); two groups of patients were treated during the course of no significant adverse reactions. Conclusion: Hormone replacement therapy is effective in treating patients with perimenopausal syndrome, effectively improving the symptoms and hormone levels of patients and protecting the endometrium with less adverse reactions, which is worthy of clinical application.