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用高脂膳食喂饲日本大耳兔，造成食饵性高脂血症，用血脂康和3种剂量的县黄醇提取物进行实验性治疗。发现喂饲高脂膳食12周后血浆TC和TG含量增高，HDL－C含量降低，同时伴有血浆LPO含量显著增高。血脂康能使TC和TG含量降低，HDL-C含量增高，但对血浆LPO含量无纠正作用。姜黄醇提取物中剂量和高剂量都能使TC和TG降低，HDL-C含量增高，同时能显著地降低LPOO含量，与正常组比较无显著差异，与模型组比较有显著差异，并且呈现量效关系。高脂膳食对PAI－l无明显变化，但能显著地增加tPA的活性，血脂康和县黄醇提取物均能降低PAI－l的活性，美黄醇提取物降PAI-1的作用有量效关系。血脂康和姜黄醇提取物均能增高tPA的活性，美黄醇提取物的作用大于血脂康，也呈现量效关系。
Feeding Japanese rabbits on a high-fat diet resulted in predilection of hyperlipidemia. Experimental treatment with Xuezhikang and 3 doses of pre-primary alcohol extracts was conducted. It was found that after 12 weeks of feeding high-fat diet, plasma TC and TG levels increased, HDL-C levels decreased, and plasma LPO levels increased significantly. Xuezhikang can reduce the content of TC and TG, increase the content of HDL-C, but it has no corrective effect on plasma LPO content. Both doses and high doses of turmeric alcohol extracts decreased TC and TG, increased HDL-C content, and significantly reduced LPOO content. There was no significant difference compared with the normal group, and there was a significant difference compared with the model group. Effect relationship. The high-fat diet had no significant change in PAI-1, but it could significantly increase the activity of tPA. Huangzhikang extract from Xuezhikang county could reduce the activity of PAI-1, and the effect of melanol extract on PAI-1 was reduced. Effect relationship. Both Xuezhikang and turmeric alcohol extracts can increase the activity of tPA. The effect of mephedol extract is greater than that of Xuezhikang and shows a dose-effect relationship.