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目的探讨葡萄糖酸锌片佐治小儿反复呼吸道感染的临床效果及对患儿免疫功能的影响。方法70例反复呼吸道感染患儿随机分为治疗组和对照组,两组均给予基础治疗,治疗组在此基础上加用葡萄糖酸锌片口服。结果治疗后70例患儿血锌、铁、钙浓度均较治疗前明显升高(P<0.05),两组治疗后免疫球蛋白G、A浓度比较差异有统计学意义(P<0.05),经治疗后9个月内发病次数治疗组为(3.05±0.88)次、对照组为(4.81±1.21)次,两组均无不良反应。结论补锌可使反复呼吸道感染患儿血清锌、免疫球蛋白G、A浓度升高,无任何不良反应,有利于儿童的生长发育,使反复呼吸道感染的发病次数明显减少,值得临床推广应用。
Objective To investigate the clinical effect of zinc gluconate on children with recurrent respiratory tract infection and its effect on immune function. Methods Seventy children with recurrent respiratory tract infection were randomly divided into treatment group and control group. Both groups were given basic treatment. On the basis of this, the treatment group was given oral zinc gluconate tablets. Results After treatment, the levels of Zinc, Iron and Calcium in 70 children were significantly higher than those before treatment (P <0.05). The immunoglobulin G and A concentrations in two groups were significantly different after treatment (P <0.05) The number of onset within 9 months after treatment was (3.05 ± 0.88) in the treatment group and (4.81 ± 1.21) in the control group, with no adverse reactions in both groups. Conclusion Zinc supplementation can increase serum zinc, immunoglobulin G and A concentrations in children with recurrent respiratory tract infection without any adverse reactions, which is beneficial to the growth and development of children and significantly reduce the incidence of recurrent respiratory tract infections, which is worthy of clinical application.