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目的探讨血小板去除术联合羟基脲、a-干扰素等药物治疗原发性血小板增多症的临床疗效及预后评价。方法对43名血小板增多症患者采用血小板去除术1—4次后,立即给予羟基脲和a-干扰素等药物治疗。结果血小板去除术后,患者外周血中血小板计数明显下降,临床症状好转,再经羟基脲、a-干扰素等药物联合治疗,所有患者病情均得到明显改善。结论血小板去除术联合羟基脲、a-干扰素治疗血小板增多症有显著疗效。
Objective To investigate the clinical efficacy and prognosis of thrombocytopenic patients combined with hydroxyurea and a-interferon in the treatment of essential thrombocythemia. Methods Forty-three patients with thrombocythemia were treated with thrombocytopenia 1-4 times immediately after treatment with hydroxyurea and a-interferon. Results After platelet removal, the platelet counts in peripheral blood of patients decreased significantly, and the clinical symptoms improved. After treatment with hydroxyurea and a-interferon, the patients’ condition were significantly improved. Conclusion Thrombocytopenia combined with hydroxyurea, a-interferon in the treatment of thrombocytosis have a significant effect.