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目的 对国产与进口头孢哌酮进行药物经济研究。方法 高效液相色谱法测定两药的人体药代动力学参数，临床观察两药治疗肺部感染患者的疗效、细菌清除、药物不良反应及治疗费用。应用成本－ 效果分析法分析成本效果比。结果 两药的体内药代动力学过程基本一致，临床有效率、细菌清除和不良反应的差异不明显，两药的成本效果比及治疗费用差别显著。结论国产头孢哌酮的作用与进口头孢哌酮无明显差异，但在成本和价格上有显著优势
Objective To study the drug economy of domestic and imported cefoperazone. Methods The human pharmacokinetic parameters of two drugs were determined by HPLC. The curative effect, bacterial clearance, adverse drug reaction and treatment cost were observed clinically in patients with pulmonary infection. Apply Cost - Effect Analysis to Analyze Cost - effectiveness Ratio. Results The in vivo pharmacokinetics of the two drugs were basically the same. There was no significant difference in clinical efficiency, bacterial clearance and adverse reactions between the two drugs, and their cost-effectiveness and treatment cost were significantly different. Conclusion The effect of domestic cefoperazone has no significant difference with imported cefoperazone, but it has obvious advantages in cost and price