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目的进一步了解中国人嗜人T细胞病毒Ⅰ型（HTLV－Ⅰ）相关性成人T细胞白血病／淋巴瘤（ATLL）外周血异形淋巴细胞超微结构特征。方法用透射电镜对最近发现的12例ATLL中4例急性型患者外周血异形淋巴细胞的超微结构进行了观察。结果主要特点为：细胞大小基本一致，与正常淋巴细胞大小相似，偶见较大的异形淋巴细胞。核为多形性，表现为切迹、凹陷、扭曲、折叠、脑回状、分叶或花瓣状。细胞器减少和发育不良，线粒体肿胀和变性。1例见类病毒颗粒。结论对ATLL细胞超微结构的认识有助于了解和探索ATLL的致病过程以及结构与功能的关系。
Objective To further understand the ultrastructural characteristics of peripheral blood heteromorphic lymphocytes in Chinese human T-cell lymphotropic type I (HTLV-I)-associated adult T-cell leukemia/lymphoma (ATLL). Methods The ultrastructural changes of peripheral blood heteromorphic lymphocytes in 4 patients with acute type of ATLL were detected by transmission electron microscopy. The main features of the results are: the cell size is basically the same, similar to the size of normal lymphocytes, and occasionally larger heteromorphic lymphocytes. The nucleus is polymorphous and is characterized by notches, depressions, distortions, folds, gyrus, lobes, or petaloids. Reduced organelles and dysplasia, mitochondrial swelling and degeneration. One case see virus-like particles. Conclusion The understanding of the ultrastructure of ATLL cells helps to understand and explore the pathogenesis of ATLL and the relationship between structure and function.