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目的：探讨中孕早期超声筛查胎儿畸形及染色体异常超声软指标的价值。方法回顾性分析我院2012年1月~2013年6月行超声检查的1730例中孕早期即孕15～20w孕妇的临床资料。结果1730例孕妇中，检查出胎儿畸形31例，占1.79%，其中单发畸形16例，复合畸形15例，包含25种胎儿畸形；检出胎儿染色体异常超声软标志91例，占5.3%，其中16例行染色体检查，有3例确诊为染色体病，占0.17%。结论中孕早期超声检查可相对较早的诊断部分胎儿结构畸形，还能联合血清学唐氏筛查和羊水染色体检查可提高胎儿染色体病的检出率，为早期干预提供依据。“,”Objective To investigate the value of ultrasound examination for fetal malformations and chromosomal abnormalities ultrasound soft markers in the early-middle pregnancy. Methods The clinical data of 1730 pregnant women in the early-middle pregnancy to 15-20 weeks who ultrasound examination in our hospital were retrospectively analyzed from January 2012 to June 2013. Results 31 cases fetal malformations were detected (1.79%,31/1730) , of which 16 cases single malformation and 15 cases complex malformation, including 25 kinds of fetal malformations.91 cases soft markers were detected (5.3%,91/1730), of which 16 cases chromosome examination, there are three cases diagnosed chromosomal disease (0.17%,3/1730). Conclusions Ultrasound examination in early-middle pregnancy can diagnose fetal structural abnormalities earlier, and combine serological screening for Downs syndrome and chromosomal examination in amniotic fluids ,which can improve the detection rate of fetalchromosomal disease,and provide foundation for early intervention.