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目的 :探讨脉络宁加多巴酚丁胺、酚妥拉明对肺心病顽固性心力衰竭的临床疗效。方法 :将 12 0例肺心病顽固性心衰随机分为西药对照组 60例 ,在吸氧 ,应用抗生素控制感染 ,合理应用强心、利尿剂及对症处理的基础上 ,采用多巴酚丁胺 2 0～ 40mg ,酚妥拉明 10～ 3 0mg加入 5 %～ 10 %葡萄糖注射液 3 0 0ml内静滴。中西药治疗组 60例 ,在西药组治疗基础上加脉络宁 3 0ml,加入 5 %～ 10 %葡萄糖注射液 2 0 0ml内静滴。两组均每日 1次 ,10～ 14天为一个疗程。结果 :中西药组临床总有效率为 95 % ,西药组总有效率为 76 6% ,两组有明显差异 (P <0 0 5 ) ;中西药组治疗前后血流变有关指标比较有显著差异 (P <0 0 1) ,而西药组无明显改变 (P >0 0 5 )。结论 :肺心病顽固性心力衰竭患者 ,在常规西药治疗基础上加用脉络宁 ,能明显提高临床疗效。
Objective: To investigate the curative effect of Mailuoning plus dobutamine and phentolamine on refractory heart failure with pulmonary heart disease. Methods: 120 cases of refractory heart failure of pulmonary heart disease were randomly divided into western medicine control group of 60 cases, in the oxygen, the application of antibiotics to control infection, the rational use of cardiac, diuretic and symptomatic treatment based on the use of dobutamine 20 ~ 40mg, Phentolamine 10 ~ 30mg 5% ~ 10% glucose injection 300ml intravenous infusion. Western medicine treatment group of 60 cases, Western medicine group based on the treatment Maillarin 30ml, adding 5% to 10% intravenous infusion of glucose 200ml. Both groups were daily 1, 10 to 14 days for a course of treatment. Results: The total clinical effective rate in Chinese and western medicine group was 95%, while the total effective rate in western medicine group was 76.6%, there was significant difference between the two groups (P <0 05); the indexes of hemorrheology in Chinese and Western medicine groups were significantly different (P <0.01), but no significant change in Western medicine group (P> 0.05). Conclusion: Pulmonary heart disease refractory heart failure patients, based on conventional western medicine plus Mailuoning, can significantly improve the clinical efficacy.