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目的 :探讨大黄粉对危重病患者肿瘤坏死因子 - α( TNF- α)、白介素 - 1 ( IL- 1 )、IL- 6的拮抗作用。方法 :2 8例患者在综合治疗的基础上经胃管给予大黄粉治疗 ,治疗前及用药后 1 d、3d、5 d、7d、1 0 d取外周静脉血检测血清 TNF- α、IL- 1、IL- 6的含量 ,并与正常对照组进行对比分析。结果 :危重病患者的 TNF- α、IL- 1和 IL- 6水平均明显高于正常对照组 ;应用大黄粉治疗后 ,患者血清 TNF- α、IL- 1和 IL- 6水平均有不同程度下降 ,至 1周后与用药前比较有显著性差异。结论 :大黄对危重病患者炎性细胞因子 TNF- α、IL- 1和 IL- 6有拮抗作用
Objective: To investigate the antagonistic effects of rhubarb powder on tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and IL-6 in critically ill patients. METHODS: Twenty-eight patients were treated with rhubarb by gastric tube on the basis of comprehensive treatment. Serum TNF-α and IL- were measured by peripheral blood before and 1 d, 3 d, 5 d, 7 d, and 10 d after treatment. 1. The content of IL-6 was compared with the normal control group. Results: The levels of TNF-α, IL-1, and IL-6 in critically ill patients were significantly higher than those in normal controls; after treatment with rhubarb powder, the levels of serum TNF-α, IL-1, and IL-6 in patients were different. Decreased to 1 week after treatment compared with significant differences. Conclusion : Rhubarb has antagonistic effects on inflammatory cytokines TNF-α, IL-1 and IL-6 in critically ill patients