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目的:观察2型糖尿病(T2DM)不同动脉血管病变中血小板计数、血小板平均体积(MPV)及血小板分布宽度(PDW)的变化情况。方法:将2012年1月至2012年10月沈阳医学院奉天医院收治的180例T2DM患者作为研究对象。根据踝臂指数(ABI)和颈动脉内膜中层厚度(IMT)分为单纯ABI≤0.9组(A组)45例、单纯IMT>0.8 mm组(B组)46例、ABI≤0.9且IMT>0.8 mm组(C组)39例、正常组(D组,ABI>0.9且IMT≤0.8 mm)50例,比较4组患者血小板计数、MPV及PDW变化。结果:A、B、C组MPV分别为11.96±0.57,11.22±1.42,12.26±0.86,与D组(9.67±1.56)比较,差异有统计学意义(P<0.05),而A、B、C组间比较差异无统计学意义(P>0.05);4组PDW和血小板计数比较,差异无统计学意义(P>0.05)。结论:T2DM动脉血管病变存在MPV增加,应加强MPV动态观察。
Objective: To observe the changes of platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) in different arterial diseases of type 2 diabetes mellitus (T2DM). Methods: 180 patients with T2DM admitted to Fengtian Hospital of Shenyang Medical College from January 2012 to October 2012 were selected as the study subjects. According to ankle-brachial index (ABI) and carotid intima-media thickness (IMT), 45 cases were divided into ABI≤0.9 group (A group), 46 cases IMT> 0.8 mm group (B group), ABI≤0.9 and IMT> 39 cases of 0.8 mm group (C group) and 50 cases of normal group (D group, ABI> 0.9 and IMT≤0.8 mm). The changes of platelet count, MPV and PDW were compared between the 4 groups. Results: The MPV of group A, B and C were 11.96 ± 0.57, 11.22 ± 1.42 and 12.26 ± 0.86 respectively, which was significantly different from that of group D (9.67 ± 1.56) (P <0.05), while A, B and C There was no significant difference between the two groups (P> 0.05). There was no significant difference in PDW and platelet count between the 4 groups (P> 0.05). Conclusion: There is an increase of MPV in T2DM arterial disease. Dynamic observation of MPV should be strengthened.