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目的:研究银杏叶提取物(EGb)对重型颅脑损伤患者血浆P-选择素(P-selectin)的影响。方法:将46例重型颅脑损伤患者随机分为治疗组和对照组,每组23例。治疗组给予EGb加20%甘露醇、胞二磷胆碱等药物常规治疗,对照组仅用20%甘露醇、胞二磷胆碱等常规治疗;观察用药前后患者症状改善程度及血浆P-selectin水平的变化。结果:两组格拉斯格恢复评分(GlasgowOutcomeScale,GOS),治疗组优于对照组(P<0.01)。重型颅脑损伤患者血浆P-selectin治疗前明显高于健康人,治疗后两组患者P-selectin水平均下降,治疗组优于对照组。结论:重型颅脑损伤患者血浆P-selectin水平升高,EGb可降低重型颅脑损伤患者血浆P-selectin水平,可能在一定程度上减轻重型颅脑损伤患者的脑损害。
Objective: To study the effect of Ginkgo biloba extract (EGb) on plasma P-selectin in patients with severe craniocerebral injury. Methods: 46 cases of severe traumatic brain injury were randomly divided into treatment group and control group, 23 cases in each group. The treatment group was given EGb plus 20% mannitol, citicoline and other drugs conventional treatment, the control group only with 20% mannitol, citicoline and other conventional treatment; observed before and after treatment in patients with symptoms and plasma P-selectin Horizontal changes. Results: Two groups of Glasgow Outcome Scale (GOS) were superior to the control group (P <0.01). P-selectin in patients with severe craniocerebral injury was significantly higher than that in healthy people before treatment, P-selectin levels decreased in both groups after treatment, and the treatment group was superior to the control group. Conclusions: Plasma P-selectin levels are elevated in patients with severe craniocerebral injury. EGb can reduce plasma P-selectin levels in patients with severe craniocerebral injury and may reduce brain damage in patients with severe craniocerebral injury to a certain extent.