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目的研究不明原因复发性流产患者的焦虑、抑郁情绪对细胞免疫功能的影响。方法随机选取2009年12月至2012年12月在甘肃省妇幼保健院就诊的120例不明原因复发性流产患者作为研究组,同期111例正常已婚育健康育龄妇女为对照组,应用抑郁自评量表(SDS)和焦虑自评量表(SAS)测评两组的焦虑、抑郁状态,同时应用流式细胞仪监测两组的细胞免疫功能—CD3+T淋巴细胞总数、CD3+CD4+T、CD3+CD8+T细胞数,计算CD4+/CD8+比值,分析不明原因复发性流产患者焦虑、抑郁情绪与细胞免疫功能的关系。结果研究组焦虑、抑郁的发生率分别为69.1%、37.4%,中重度占14.1%、11.6%,对照组焦虑、抑郁的发生率分别为11.7%、6.3%,中重度占1.8%、1.8%(χ2=78.703,P<0.01;χ2=32.338,P<0.01)。研究组外周血CD3+CD8+T细胞低于对照组(t=7.467,P<0.01),而CD4+/CD8+比值较对照组明显增高(t=5.248,P<0.01);经Pearson相关分析显示研究组焦虑、抑郁程度与CD4+/CD8+比值呈正相关(r=0.201,P<0.05;r=0.223,P<0.05)。结论不明原因复发性流产患者焦虑、抑郁的发生率明显高于正常育龄期妇女。其焦虑、抑郁程度影响机体的细胞免疫功能,也是引起反复流产的重要原因。
Objective To study the effects of anxiety and depression on cell immune function in patients with unexplained recurrent spontaneous abortion. Methods A total of 120 cases of unexplained recurrent spontaneous abortion in Gansu Province Maternal and Child Health Hospital were randomly selected from December 2009 to December 2012 as the research group and 111 normal healthy married healthy women of childbearing age as the control group. (SDS) and anxiety scale (SAS) were used to evaluate the anxiety and depression status of the two groups. At the same time, the cell immune function-CD3 + T lymphocyte count, CD3 + CD4 + T, CD3 + CD8 + T cell count, calculate the ratio of CD4 + / CD8 +, analysis of unexplained recurrent spontaneous abortion patients with anxiety, depression and the relationship between cellular immune function. Results The incidence of anxiety and depression were 69.1% and 37.4% in the study group, 14.1% and 11.6% respectively in the moderate and severe groups. The incidences of anxiety and depression in the control group were 11.7% and 6.3%, 1.8% and 1.8% (χ2 = 78.703, P <0.01; χ2 = 32.338, P <0.01). The percentage of CD3 + CD8 + T cells in peripheral blood of the study group was lower than that of the control group (t = 7.467, P <0.01), while the ratio of CD4 + / CD8 + was significantly higher than that of the control group (t = 5.248, Group anxiety and depression were positively correlated with CD4 + / CD8 + ratio (r = 0.201, P <0.05; r = 0.223, P <0.05). Conclusions The incidence of anxiety and depression in patients with unexplained recurrent spontaneous abortion is significantly higher than that of normal women of childbearing age. Its anxiety and depression affect the body’s cellular immune function, but also cause repeated abortion is an important reason.