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目的探讨乳腺癌组织中P-gp、MRP表达与腋窝淋巴结转移的关系。方法34例乳腺浸润性导管癌患者接受回顾性研究,其中18例经病理证实腋窝淋巴结转移。免疫组织化学技术分别检测术后癌组织标本中P-gp、MRP表达,比较P-gp阳性组和阴性组患者间、MRP阳性组和阴性组患者间腋窝淋巴结转移的差异。结果34例乳腺癌患者中,P-gp阳性表达率64.71%(22/34),MRP阳性表达率38.24%(13/34),两者共表达率20.59%(7/34)。P-gp表达阳性22例中,腋窝淋巴结转移12例,P-gp阴性表达12例,腋窝淋巴结转移6例,两组间腋窝淋巴结转移差异无统计学意义(P=1.000,双侧);MRP表达阳性13例中,腋窝淋巴结转移8例,MRP阴性表达21例,腋窝淋巴结转移10例,两组间腋窝淋巴结转移差异无统计学意义(P=0.433,双侧)。结论乳腺浸润性导管癌P-gp、MRP表达与腋窝淋巴结转移无关;P-gp、MRP表达不能赋予恶性肿瘤细胞更强的侵袭能力。
Objective To investigate the relationship between P-gp, MRP expression and axillary lymph node metastasis in breast cancer. Methods A total of 34 patients with invasive ductal carcinoma of the breast received a retrospective study, of which 18 cases were pathologically confirmed axillary lymph node metastases. Immunohistochemistry was used to detect the expression of P-gp and MRP in the specimens of postoperative cancer tissues. The differences of axillary lymph node metastasis between the positive and negative group were compared between patients with P-gp positive and negative. Results The positive expression rate of P-gp was 64.71% (22/34) in 34 cases of breast cancer, the positive rate of MRP was 38.24% (13/34), the positive rate of P-gp was 20.59% (7/34). In 22 cases with P-gp positive expression, there were 12 cases of axillary lymph node metastasis, 12 cases of P-gp negative expression and 6 cases of axillary lymph node metastasis. There was no significant difference in axillary lymph node metastasis between the two groups (P = 1.000, both sides); MRP Positive expression of 13 cases of axillary lymph node metastasis in 8 cases, MRP negative expression in 21 cases, axillary lymph node metastasis in 10 cases, axillary lymph node metastasis between the two groups was no significant difference (P = 0.433, bilateral). Conclusion The expression of P-gp and MRP in invasive ductal carcinoma of the breast has no relationship with the axillary lymph node metastasis. The expression of P-gp and MRP can not confer stronger invasion ability to malignant tumor cells.