Daily and weekly sea surface temperature data of Tropical Rainfall Measuring Mission (TRMM) Microwave Imager and Advanced Microwave Scanning Radiometer-Earth Observing System sensors are used as forcing of the underlying sea surface in the mesoscale numerical model to simulate Typhoon Dujuan that moved across the South China Sea in 2003. The numerical results show that different SSTs near the typhoon center result in differences in the atmospheric wind field, indicating that the model has a fast and obvious response to SSTs. Different SST influences the intensity and track of Dujuan to some degree and has significant impacts on its precipitation and latent heat flux near the eye. The SST influence on Dujuan is mainly fulfilled by changing the latent heat flux between the ocean surface and the atmosphere above.