论文部分内容阅读
局灶节段性肾小球硬化(focal segmental glomerulosclerosis,FSGS)是一组病因和发病机制各异的临床病理综合征,临床主要表现为大量蛋白尿甚至肾病综合征,病理特征为部分肾小球发生节段性硬化和足突融合。哥伦比亚病理分型标准按照光镜下改变将FSGS分为5种亚型:塌陷型、顶端型、细胞型、门周型和非特异型。哥伦比亚病理分型标准重在强调临床病理联系,并未完全阐明FSGS的发病机制以及5种亚型的病理生理学基础。近年来关于FSGS的发病机制及其不同病理亚型的形态学发生基础的研究取得了较大的进展,本文就相关内容作一综述。
Focal segmental glomerulosclerosis (FSGS) is a group of clinicopathological syndromes with different etiology and pathogenesis. The main clinical manifestations are massive proteinuria and nephrotic syndrome. The pathological features are partial glomerulus Occurrence of segmental sclerosis and foot process fusion. Columbia pathological classification according to light microscopic changes in the FSGS will be divided into five subtypes: collapse, apical, cell type, perimenional and nonspecific. The emphasis placed on colorectal cancer pathology is to emphasize the relationship between clinicopathology and pathology. The pathogenesis of FSGS and the pathophysiology of the five subtypes are not fully elucidated. In recent years, the pathogenesis of FSGS and morphological basis of different pathological subtypes have made great progress, this article reviews the related content.