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内源性前列腺素,尤其是PGE_2和PGI_2在维持胃粘膜的正常结构与功能方面起着十分重要的作用。大量实验结果支持这一假说,前列腺素合成减少可能参与了酒精引起的胃粘膜损伤。本研究旨在探讨长期饮酒对胃粘膜中PGE_2和PGF_(2α)合成的影响。 方法:122例因上消化道症状(饱胀、疼痛或烧心感等)而行胃镜检查患者分为两组:56
Endogenous prostaglandins, especially PGE 2 and PGI 2, play an important role in maintaining the normal structure and function of gastric mucosa. Numerous experimental results support the hypothesis that reduced prostaglandin synthesis may be involved in alcohol-induced gastric mucosal injury. This study aimed to investigate the effects of chronic alcohol consumption on the synthesis of PGE 2 and PGF 2α in gastric mucosa. METHODS: One hundred and twenty-two patients undergoing gastroscopy due to upper gastrointestinal symptoms (fullness, pain or heartburn, etc.) were divided into two groups: 56