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目的观察奥施康定经直肠给药对晚期癌痛的临床疗效及不良反应。方法奥施康定10～200mg经直肠给药塞入距肛门2～4cm处,每12h塞药1次。根据癌痛缓解程度调整用药量,连用2周后评价疗效。结果完全缓解(CR)27例(49.1%),部分缓解(PR)23例(41.8%),轻度缓解(MR)5例(9.1%),无效(NR)0例(0),总有效率(完全缓解+部分缓解)达到90.9%。结论奥施康定直肠给药止痛效果确切可靠,且无严重不良反应,可作为不能口服止痛药的癌性疼痛患者的较好选择。
Objective To observe the clinical efficacy and adverse reactions of Oxycodin delivered by rectum for advanced cancer pain. Methods Oxycodone 10 ~ 200mg rectal administration stuffing 2 ~ 4cm away from the anus, Cypriot medicine every 12h. According to the degree of cancer pain to adjust the dosage, once every 2 weeks after the evaluation of efficacy. Results There were 27 cases (49.1%) of complete remission (CR), 23 cases (41.8%) of partial remission (PR), 5 cases (9.1%) of mild remission Efficiency (complete remission + partial remission) reached 90.9%. Conclusion Oxycycline rectal administration of analgesic effect is reliable, and no serious adverse reactions, can not be used as a painkiller oral cancer patients with a better choice.