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为研究抗组蛋白抗体(AHA)在局限性硬皮病患者中的发生率和抗原特异性,作者使用酶联免疫吸附法(ELISA)和免疫印迹法对49例局限性硬皮病患者的血清进行检测。患者男性12例,女性37例,年龄4～66岁(平均24.4岁),其中泛发性硬斑病15例,线状硬皮病22例,硬斑病12例。同时设立3个对照组;正常人
To investigate the incidence and antigen specificity of anti-histone antibodies (AHA) in patients with localized scleroderma, the authors used enzyme-linked immunosorbent assay (ELISA) and immunoblotting to detect the serum levels of 49 patients with localized scleroderma Test. There were 12 males and 37 females, ranging in age from 4 to 66 years old (average 24.4 years). Among them, 15 cases were acute sclerotisis, 22 cases were linear scleroderma and 12 cases were hard spot. At the same time set up three control groups; normal people