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最近,有两组不同的证据强调了感染在癌症发生中的作用.首先是Calvert等研究了慢性胃炎与胃粘膜相关淋巴组织(MALT)淋巴瘤之间的关系,发现某些胄MALT淋巴瘤的等位基因不平衡,位于抑制瘤基因DCC和APC的微卫星灶中,而不在有炎症的周围粘膜部位,认为这种变化在结直肠癌的发生上是重要的.通过多聚酶链反应还发现组织学上无争议的慢性胃炎也可有单克隆淋巴细胞浸润,慢性胃炎与MALT淋巴瘤的关系越来越被肯定.另一个重要资料是新的动物模型.用螺杆菌使裸鼠感染导致带有恶性组织学特征的淋巴细胞增生,从而拓宽了胃淋巴瘤发生的研究领域.此外,感染与肿瘤性淋巴细胞增生之间的联系并不局限于胃.包柔氏螺旋体属感染能诱发一种皮肤相关性淋巴组织的良性增生,称之为真皮淋巴细胞瘤病,皮肤相关性淋巴组织是MALT系统的另一组成部分.
Recently, two sets of different evidence have emphasized the role of infection in the development of cancer. First, Calvert et al. studied the relationship between chronic gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphomas, and found that some of the 胄MALT lymphomas The allele is not balanced and is located in the microsatellite foci of the tumor suppressor genes DCC and APC, but not in the surrounding mucosal areas with inflammation. This change is thought to be important in the development of colorectal cancer. Tissues are also found by polymerase chain reaction Academically, non-controversial chronic gastritis may also have monoclonal lymphocytic infiltration, and the relationship between chronic gastritis and MALT lymphoma is increasingly being confirmed. Another important data is the new animal model. Infection with nude mice caused by Helicobacter Malignant histological features of lymphocyte proliferation have broadened the field of gastric lymphomagenesis. In addition, the link between infection and neoplastic lymphocytosis is not limited to the stomach. The infection of the genus Borrelia can induce a skin type. Benign hyperplasia of associated lymphoid tissue, known as dermal lymphoblastic disease, skin-associated lymphoid tissue is another component of the MALT system.