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为探讨ＣＤ４４ｖ６表达与大肠癌转移及预后的关系，对１０１例大肠癌存档石蜡组织标本进行重新切片，采用ＣＤ４４ｖ６鼠单克隆抗体进行免疫组化染色（ＬＳＡＢ法）。结果发现ＣＤ４４ｖ６表达与年龄、性别、肿瘤大小、部位、组织类型无关；与Ｄｕｋｅｓ分期、淋巴结转移、其它脏器转移和根治术后复发有关；ＣＤ４４ｖ６表达阳性者术后生存率较表达阴性者低（Ｐ＜０．０１）。结果表明：ＣＤ４４ｖ６在大肠癌转移和复发中具有一定的作用，可能成为预测大肠癌转移和预后的生物学指标之一。
To investigate the relationship between the expression of CD44v6 and the metastasis and prognosis of colorectal cancer, 101 paraffin-embedded specimens of colorectal cancer were re-sectioned and CD44v6 murine monoclonal antibody was used for immunohistochemical staining (LSAB method). The results showed that CD44v6 expression was not related to age, gender, tumor size, location, and tissue type; it was related to Dukes stage, lymph node metastasis, other organ metastasis, and recurrence after radical resection; the survival rate of CD44v6 positive was lower than that of negative expression. (P<0.01). The results showed that: CD44v6 has a certain role in the metastasis and recurrence of colorectal cancer, and may be one of the biological indicators to predict the metastasis and prognosis of colorectal cancer.