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天然产物一直是药物开发的重要来源,除少部分作为药品直接应用于临床外,大部分都作为先导药物,经过化学修饰等衍生出一系列相关药物。大量的天然产物及其衍生物已在疾病治疗、新药研发和生命科学(包括医学)研究等领域得到广泛应用。癌症化疗一定程度上也受惠于天然产物,已有多种化合物在肿瘤临床治疗方面取得巨大成功,其中以长春花碱和紫杉醇等构成的微管抑制剂最为典型。长春花碱的发现和应用长春花碱(Vinblastine)是较早应用于癌症治疗的天然产物,而它的发现源于一次偶然。爱德华·克里克·诺布尔
Natural products have always been an important source of drug development. Most of them are used as lead drugs except for a small part as drugs directly applied to the clinic, resulting in a series of related drugs derived from chemical modification. A large number of natural products and their derivatives have been widely used in the fields of disease treatment, drug discovery and life science (including medicine) research. Chemotherapy for cancer has also benefited from natural products to some extent. There are many compounds that have achieved great success in the clinical treatment of tumors. Among them, microtubule inhibitors such as vinblastine and paclitaxel are most typical. Discovery and application of vinblastine Vinblastine is a natural product that has been used in cancer treatment earlier, and its discovery stems from a chance. Edward Crick Noble