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目的:探讨妊娠期肝内胆汁淤积症(ICP)血小板变化的临床意义,为临床观察提供参考依据。方法:109例ICP为观察组,121例健康孕妇为对照组,测定血小板参数、血生化参数,比较分析。结果:观察组血小板计数下降、血小板平均体积、血小板分布宽度、大血小板比例,较对照组明显增加,差异有统计学意义(P<0.05或P<0.01)。观察组血小板平均体积与血浆甘胆酸水平之间呈低度正相关(r为0.21,P<0.05)。结论:ICP患者血小板参数测定,可以作为ICP病情观察的辅助参考指标,有助于减少产后出血的医学干预,保护母婴健康。
Objective: To investigate the clinical significance of platelet changes in intrahepatic cholestasis of pregnancy (ICP) and provide a reference for clinical observation. Methods: 109 cases of ICP group and 121 healthy pregnant women as control group, platelet parameters, blood biochemical parameters were measured and compared. Results: The decrease of platelet count, the average volume of platelets, the distribution of platelets and the proportion of large platelets in the observation group were significantly higher than those in the control group (P <0.05 or P <0.01). There was a low positive correlation between mean platelet volume and plasma glycocholic acid level in the observation group (r = 0.21, P <0.05). Conclusion: The determination of platelet parameters in ICP patients can be used as an auxiliary reference for ICP observation, which can help reduce postpartum hemorrhage and prevent maternal and child health.