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本文介绍了一种非常灵敏并可应用于法医毒物分析的核酸适配体识别技术。这种技术可与多种分析技术手段联用而检测毒物和药物,技术手段包括阻抗滴定技术、表面增强拉曼技术、荧光检测技术、微流控芯片技术、表面等离子共振技术等。核酸适配体技术的检测优势主要表现为选择性强,并且通过纳米金颗粒修饰,可以极大的增强检测信号,实现对痕量目标分子的精准检测。核酸适配体技术由于其易于合成、造价低廉、操作简便、精准识别等优势必将会受到法庭科学家的重视而广泛应用于未来的法医毒物药物分析工作中。
This article describes a very sensitive aptamer aptamer technology that can be applied to forensic toxicology analysis. This technology can be used in conjunction with a variety of analytical techniques to detect poisons and drugs. Techniques include impedance titration, surface-enhanced Raman spectroscopy, fluorescence detection, microfluidic chip technology and surface plasmon resonance. The advantages of aptamer technology are mainly selective and the detection signals can be greatly enhanced by the modification of nano-gold particles to achieve accurate detection of trace amounts of target molecules. Because of its easy synthesis, low cost, easy operation, precise identification and other advantages, nucleic aptamer technology will be widely applied to forensic analysis of toxic drugs in the future due to the attention of forensic scientists.